Lactulose-Mannitol Intestinal Permeability Test: A Useful Screening Test for Adult Coeliac Disease

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Is the sugar intestinal permeability test a reliable investigation for coeliac disease screening?

BACKGROUND The lactulose/mannitol (L/M) intestinal permeability test is a simple, non-invasive screening test for coeliac disease. The reliability of the L/M test has so far only been tested in selected groups of patients with coeliac disease. AIM To evaluate the reliability of the L/M test in a group of patients with coeliac disease who had been diagnosed during mass serological screening of...

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Screening test for coeliac disease.

Ose, L., and Fluge, G. (1974). The D-xylose tolerance test as screening test for malabsorption disorders in infancy and and childhood. Tidsskrift for Den Norske Legeforening, 94, 1192. Rolles, C. J., Anderson, C. M., and McNeish, A. S. (1975). Confirming persistence of gluten intolerance in children diagnosed as having coeliac disease in infancy: usefulness of one-hour blood xylose test. Archiv...

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Assessment of the lactulose-mannitol test in Crohn's disease.

The mannitol-lactulose intestinal permeability test was evaluated in 100 healthy controls and 47 patients with Crohn's disease. These patients were further separated into three subgroups of increased activity (Harvey-Bradshaw index) and in two subgroups, with elective colonic lesions and associated ileal and colonic lesions. Results were given as percentages of urinary recoveries for mannitol (...

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Cellobiose/mannitol sugar test--a sensitive tubeless test for coeliac disease: results on 1010 unselected patients.

The cellobiose/mannitol (Ce/Ma) test is a non-invasive technique for investigating intestinal permeability. In coeliac disease there is a decreased absorption of small molecules and paradoxically increased absorption of large molecules. The simultaneous administration of cellobiose and mannitol as two probe molecules allows the permeability of the small bowel mucosa to be studied, eliminating e...

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Intestinal permeability and screening tests for coeliac disease.

In disease states of the small intestine--for example, gluten-sensitive enteropathy--there is an increased permeability to large molecules. This increased permeability extends to polar molecules of intermediate size such as disaccharides, whereas small polar molecules are malabsorbed. A recently-developed oral test, based on the simultaneous administration of two test substances, cellobiose (a ...

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ژورنال

عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine

سال: 2000

ISSN: 0004-5632,1758-1001

DOI: 10.1177/000456320003700413